For Research Use Only. Not for Use in Diagnostic Procedures
The MicroVue tDPD kit provides reagents for hydrolysis of specimens and measurement of total Dpd in urine and serum.
Reagents and controls for assaying total deoxypyridinoline (Dpd) crosslinks in serum or urine.
In humans, the total pool of urinary Dpd is approximately 45% free while the remaining fraction is bound to oligopeptides ranging from small linear peptides to very large cross-linked structures in excess of 10,000 Da. Free and total cross-links appear in healthy individuals and those with metabolic bone diseases, thus providing the rationale for measuring the combined total forms of Dpd. Improvements in immunoassay methodology have resulted in the ability to measure Total Dpd level in serum and urine thus permitting a novel method for researching bone specific collagen degradation.
-
Allows quantitative measure of Dpd in serum
-
Results in urine are comparable to HPLC
