SirReal2,Sirt2Inhibitor
如果您對該產品感興趣的話,可以
產品名稱: SirReal2,Sirt2Inhibitor
產品型號: M60289-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
SirReal2,Sirt2Inhibitor
SirReal2,Sirt2Inhibitor
的詳細介紹
Product Information
| Molecular Weight: |
420.55 |
| Formula: |
C22H20N4OS2 |
| Purity: |
≥98% |
| CAS#: |
709002-46-0 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
SirReal2 is a
potent and selective Sirt2 inhibitor with IC50? ~140 nM, has minimal effect on Sirt1 and
Sirt3-6. It occupies the extended C-site and induces a major rearrangement of
Sirt2’s active site, so it selectively inhibits Sirt2 and functions as a
molecular wedge to lock Sirt2 in an open conformation. SirReal2 can increase
tubulin hyperacetylation in HeLa cells and induces destabilization of the
checkpoint protein BubR1. It could be a useful chemical tool for sirtuin
biology.
How to use:?
In vitro: SirReal2 was used at 10-20 μ M final concentration in vitro and in cellular assays.
In vivo: n/a?
Reference:- 1. Rumpf T, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. (2015) Nat Commun. 6:6263.?
? ? ??
Products are for research use only. Not for human use.?
