PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
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產品名稱: PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
產品型號: M60182-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
PFI-2,SETD7HistoneLysineMethyltransferaseInhibitor
的詳細介紹
Product Information
| Molecular Weight: |
499.52 |
| Formula: |
C23H25F4N3O3S
|
| Purity: |
≥98% |
| CAS#: |
1627676-59-8 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
(R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.
How to Use:
- In vitro: PFI-2 was used at 1 μM in vitro.
- In vivo: n/a
Reference:
- 1. http://www.thesgc.org/chemical-probes/epigenetics
Products are for research use only. Not for human use.
