Anti-L-Ficolin (human) ABS 005-19
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產(chǎn)品名稱: Anti-L-Ficolin (human) ABS 005-19
產(chǎn)品型號: ABS 005-19
產(chǎn)品展商: Bioporto
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Anti-L-Ficolin (human)
Anti-L-Ficolin (human) ABS 005-19
的詳細介紹
- Product name
- Anti-L-Ficolin (human)
- Description
-
Mouse monoclonal antibody
- Specificity
ABS 005-19 reacts specifically with L-Ficolin. No cross reactivity is seen with M-Ficolin (Ficolin-1) and H-Ficolin (Ficolin-3).
- Immunogen
Purified procaryot expressed recombinant human L-Ficolin and full-length L-Ficolin (Ficolin-2) protein?
- Species reactivity (positive)
- Human
- Species reactivity (negative)
- Not determined
- Content
Available in 200 μL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
- Purification
- Protein-A purified
- Solvent
- 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
- Storage
- 4-8oC without exposure to light. No precautions necessary during handling.
- Target
L-Ficolin (Ficolin-2) is an innate immunity pattern recognition molecule found in human serum. L-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP), such as carbohydrates (GlcNAc), lipoteichoic acid and acetylated groups thereby facilitating phagocytosis and activation of complement through the lectin route using the same serine proteases as mannose-binding lectin (MBL) named MASP ((MBL)-associated serine protease) (1).
- Application 1
ELISA
ABS 005-19 is especially well suited as detecting antibody in a sandwich ELISA in combination with ABS 005-16 (1). Furthermore, in ELISA, ABS 005-19 reacts with recombinant L-Ficolin coated directly into the microtiter well.
- Application 2
WB
ABS 005-19 can be used in Western blotting (1, 2, 3)
?
- Application 3
IP
ABS 005-19 can be used in immunoprecipitation (4).
1. ?Munthe-Fog L, Hummelsh?j T, Hansen BE, Koch C, Madsen HO, Skj?dt K, Garred P (2007) The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels. Scand J Immunol 65:383-392.
-
17386030
2. Jensen ML, Honoré C, Hummelshoj T, Hansen BE, Madsen HO, Garred P (2006) Ficolin-2 recognizes DNA and participates in the clearance of dying host cells. Mol Immunol 44:856-865.
-
16730064
3. Hummelshoj T, Thielens NM, Madsen HO, Arlaud GJ, Sim RB, Garred P (2006) Molecular organization of human Ficolin-2. Mol Immunol 44:401-411.
-
16595153
4. Skjoedt MO, Hummelshoj T, Palarasah Y, Honore C, Koch C, Skjodt K, Garred P (2010) A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement Activation. J Biol Chem 285:8234-8243.
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20053996
