α-conotoxin-PeIA
Discriminates between α9α10 and α7 nAChRs
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產品名稱: α-conotoxin-PeIA
Discriminates between α9α10 and α7 nAChRs
產品型號: 13CON017-00100
產品展商: 其他品牌
產品文檔: 無相關文檔
簡單介紹
α-conotoxin-PeIA
Discriminates between α9α10 and α7 nAChRs
α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 μM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97
α-conotoxin-PeIA
Discriminates between α9α10 and α7 nAChRs
的詳細介紹
α-conotoxin-PeIA
Discriminates between α9α10 and α7 nAChRs
α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 μM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 μM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.
