Waglerin-1
Waglerin-1 blocks muscle-type nAChRs
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產(chǎn)品名稱: Waglerin-1
Waglerin-1 blocks muscle-type nAChRs
產(chǎn)品型號(hào): 12WAG001-01000
產(chǎn)品展商: 其他品牌
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簡(jiǎn)單介紹
Waglerin-1
Waglerin-1 blocks muscle-type nAChRs
Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of muscle nicotinic acetylcholine receptors. Waglerin-1 competes with α-bungarotoxin.
Waglerin-1 is an interesting tool to discriminate between fetal and ***** muscle nAChRs as i
Waglerin-1
Waglerin-1 blocks muscle-type nAChRs
的詳細(xì)介紹
Waglerin-1
Waglerin-1 blocks muscle-type nAChRs
Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of muscle nicotinic acetylcholine receptors. Waglerin-1 competes with α-bungarotoxin.
Waglerin-1 is an interesting tool to discriminate between fetal and ***** muscle nAChRs as it binds to the α-_x000f_ε subunit interface with a ~ 2000 fold higher affinity than to the α-γ or α-δ subunits. Waglerin-1 is known to bind 100 fold more potently to nAChR from ***** mice than that from rat or humans. It blocks muscle nAChR from ***** mice with an IC50 value of 50nM.
Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons.
Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles.
